Nestabs - Womens Choice Pharmaceuticals

An Old Favorite With A New Formulation

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Iron

Ferrous (II) bis-Glycinate Chelate is a novel form of iron that is easier to absorb, associated with fewer side effects, and less toxic than standard supplements like ferrous sulfate.1

• Clinically proven to reduce negative side effects especially bloating, constipation, and nausea when compared to ferrous sulfate.2

• Compliant with the CDC’s recommendation for preventing and controlling iron deficiency anemia in pregnant women through low dose supplementation

Folic Acid

• Folic Acid is shown to significantly reduce the incidence of neural tube defects in unborn babies.3

Vitamin B6

Vitamin B6 is recommended as a first-line therapy for pregnancy-related nausea and vomiting by the American College of Obstetricians and Gynecologists (ACOG)7

• Nestabs® contains 50 mg of vitamin B6 which has been shown to reduce pregnancy-related nausea.8,9

Choline

Choline is designated as an essential nutrient by the FDA with supplementation during pregnancy linked to improved memory skills of children.

• Influences neural tube closure10

• Plays a critical role in normal brain development11

• May result in lifelong enhancement of memory and attention12

Calcium Formate

Nestabs® contains FormiCal® a patented source of calcium formate. FormiCal® is superior to both calcium carbonate and calcium citrate in its ability to deliver calcium to the bloodstream and depress iPTH after oral administration.13

• Formical® is clinically proven to be:

• More soluble and much more absorbed than other calciums

• Avoids bloating common with calcium

After calcium formate administration, the Cmax and AUC values were double those for calcium citrate. The large and highly significant increases in these parameters indicate that calcium from calcium formate is absorbed much more rapidly and to a much greater extent than calcium from the other calcium preparations studied.

ABBREVIATIONS: iPTH, intact parathyroid hormone 1–84; AUC, area under the plasma concentration-time curve

Nestabs® tablets include 14 essential vitamins, minerals, and trace elements to adequately supplement mothers and unborn children.

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Nestabs® is nutritionally complete and was carefully formulated using recommendations from the American College of Obstetrics and Gynecology and the Center for Disease Control

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Nestabs® is a well tolerated film coated tablet with a pleasant sweet flavor

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Nestabs® is a Kosher certified tablet, Gluten free and Vegetarian

Distributed by: Women’s Choice Pharmaceuticals Formical® is a registered trademark of Nephro-Tech 1, LLC

US Patent #6,528,542

Nestabs® is a registered trademark of Women’s Choice Pharmaceuticals, LLC

NDHA – 10/10

REFERENCES

1 Data on file, Womens Choice Pharmaceuticals

2 Coplin M, Schuette S, Leichtmann G, Lashner B. Tolerability of iron: a comparison of bis-glycino iron II and ferrous sulfate. Clin Ther. 1991 Sep-Oct;13(5):606-12

3 Center for Disease Control and Prevention. Recommendations for use of Folic Acid to reduce number of spina bifida cases and other neural tube defects, MMWR. 1992.41:RR-14.

4 Smut, et al. Obstetrics and Gynecology, 2003; 101:469-79

5 Jensen et al. American Journal of Clinical Nutrition 2005; 82:125-32.

6 Hibbeln JR, Journal of Affective Disorders, May 2002; 69:15-29

7 American College of Obstetricians and Gynecologists (ACOG). Nausea and vomiting of pregnancy. ACOG Practice Bulletin. 2004;52:1-10

8 Sahakian V, Rouse D, Sipes S, Rose N, Niebyl J. Vitamin B6 is an effective therapy for nausea and vomiting of pregnancy, double blind placebo-controlled trial. Ob Gyn.1991; 78: 33-36

9 Vutyavanvanich T, Wongra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled trial. Am J Ob Gyn. 1995; 173: 881-884

10 Zeisel SH: Nutrition; 2000; 16:669-671

11 Zeisel SH: Journal of the American College of Nutrition; 1992; 11:473-481

12 Loy R, Heyer D, Williams CL, Merk WH, Advances in Experimental Medicine and Biology 1991; 295:373-382